Mechanisms of phytoestrogen biochanin A-induced vasorelaxation in renovascular hypertensive rats
نویسندگان
چکیده
منابع مشابه
Mechanisms of phytoestrogen biochanin A-induced vasorelaxation in renovascular hypertensive rats
BACKGROUND The plant-derived estrogen biochanin A is known to cause vasodilation, but its mechanism of action in hypertension remains unclear. This study was undertaken to investigate the effects and mechanisms of biochanin A on the thoracic aorta in two-kidney, one clip (2K1C) renovascular hypertensive rats. METHODS Hypertension was induced by clipping the left renal artery, and control age-...
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In spite of the well-known contribution of angiotensin II (Ang II) in the pathogenesis of Goldblatt two-kidney one clip (G2K1C) hypertension, the importance of other Ang peptides, such as Ang III, Ang IV or Ang 2-10, is scarcely understood. The functional status of these peptides depends on the action of several aminopeptidases called angiotensinases. The metabolism of Ang III to Ang IV by amin...
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Biochanin A (BCA) is a natural organic compound of the phytoestrogenic isoflavone class that has antioxidant and metal chelator properties in the presence of transition metal ions, however, its efficacy in animal models is still obscure. Therefore, the objective of this study was to investigate the protective effects of BCA against arsenic-induced hepatic injury and hematotoxicity in rats. The ...
متن کاملChanges in cardiac adrenomedullin concentration in renovascular hypertensive rats.
We assessed changes in tissue and plasma adrenomedullin levels in two-kidney, one-clip renovascular hypertensive rats. Four weeks after clipping, adrenomedullin concentrations were significantly higher in the cardiac ventricles and lower in the left atrium than the respective values in sham-operated rats. The left ventricular adrenomedullin concentration significantly correlated with systolic b...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2014
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2014.08.003